Deborah Ann (Napolitano) Lowe, a woman whose life centered around her family and friends, died at Massachusetts General Hospital on August 15, 2022, following a courageous battle with cancer. She was 66, and a lifelong resident of Maynard. Born in Concord on April 26, 1956, she was the daughter of the late Frederick and Patricia (Cullinane) Napolitano. Debbie graduated from Maynard High School with the class of 1974, and for eleven years, owned and operated a Daycare Service out of her residence. She was the beloved wife for 43 years of Brian H. Lowe of Maynard, the dedicated mother of April Lowe and her husband Jason of Framingham, and the proud grandmother of Chloe and Reid. She also leaves behind two brothers, one sister and several nieces and nephews. Family and friends will gather for visiting hours on Monday, August 22nd from 4 to 7 pm in the Dee Funeral Home, 27 Bedford Street, Concord Center. Her funeral will be held on Tuesday, August 23rd at 9:30 am from Dee Funeral Home, followed by a Funeral Mass at 10:30 am in Holy Family Parish, Monument Square, Concord Center. Burial will follow at St. Bernard's Cemetery, Concord. In lieu of flowers, donations in her memory may be made to the American Cancer Society . Arrangements are under the care of Dee Funeral Home & Cremation Service of Concord.